Oxazepines and Thiazepines, XXV: Chemical Transformations of 2,3‐Dihydro‐1,5‐benzothiazepin‐4(5H)‐ones

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Abstract

2,3‐Dihydro‐1,5‐benzothiazepine‐4(5H)‐thiones 13‐22 were prepared by the reaction of the appropriate 2,3‐dihydro‐1,5‐benzothiazepin‐4(5H)‐ones with Lawesson's reagent. N‐Acyl (23‐25) and N‐alkyl (26‐28) derivatives have also been synthesized. Oxidation with 3‐chloroperoxybenzoic acid afforded sulfoxides 29‐32, and sulfones 33‐40 were obtained by using H2O2 as an oxidizing agent.

Original languageEnglish
Pages (from-to)721-726
Number of pages6
JournalArchiv der Pharmazie
Volume325
Issue number11
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

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