Oxazepines and thiazepines, XXV: Chemical transformations of 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones

Research output: Contribution to journalArticle

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Abstract

2,3-Dihydro-1,5-benzothiazepine-4(5H)-thiones 13-22 were prepared by the reaction of the appropriate 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones with Lawesson's reagent. N-Acyl (23-25) and N-alkyl (26-28) derivatives have also been synthesized. Oxidation with 3-chloroperoxybenzoic acid afforded sulfoxides 29-32, and sulfones 33-40 were obtained by using H2O2 as an oxidizing agent.

Original languageEnglish
Pages (from-to)721-726
Number of pages6
JournalArchiv der Pharmazie
Volume325
Issue number11
DOIs
Publication statusPublished - 1992

Fingerprint

2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide
Thiazepines
Oxazepines
Sulfoxides
Thiones
Sulfones
Oxidants
Derivatives
Oxidation
1,5-benzothiazepine
3-chloroperbenzoic acid

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Oxazepines and thiazepines, XXV : Chemical transformations of 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones. / Lévai, A.

In: Archiv der Pharmazie, Vol. 325, No. 11, 1992, p. 721-726.

Research output: Contribution to journalArticle

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