Oxazepines and thiazepines, XXIV synthesis of optically active 2,3-dihydro-2-methyl-1,5-benzoxazepin-4(5 H)-ones

Albert Lévai, Jürgen Ott, Günther Snatzke

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

2,3-Dihydro-2(R)-methyl-1,5-benzoxazepin-4(5 H)-one [(R)-3] and its enantiomer (S)-3 have been synthesized via the optical resolution and subsequent chemical transformations of (±)-3-(2-nitrophenoxy)butyric acid (1). Compounds (R)-3 and (S)-3 were converted into optically active 1,5-benzoxazepines (R)-7-(R)-14 and (S)-15-(S)-32.

Original languageEnglish
Pages (from-to)919-930
Number of pages12
JournalMonatshefte für Chemie Chemical Monthly
Volume123
Issue number10
DOIs
Publication statusPublished - Oct 1 1992

Keywords

  • Catalytic hydrogenation
  • Determination of absolute configuration
  • Determination of optical purity
  • Optical resolution
  • Ring closure of aminocarboxylic acids

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Oxazepines and thiazepines, XXIV synthesis of optically active 2,3-dihydro-2-methyl-1,5-benzoxazepin-4(5 H)-ones'. Together they form a unique fingerprint.

  • Cite this