2,3-Dihydro-2(R)-methyl-1,5-benzoxazepin-4(5 H)-one [(R)-3] and its enantiomer (S)-3 have been synthesized via the optical resolution and subsequent chemical transformations of (±)-3-(2-nitrophenoxy)butyric acid (1). Compounds (R)-3 and (S)-3 were converted into optically active 1,5-benzoxazepines (R)-7-(R)-14 and (S)-15-(S)-32.
- Catalytic hydrogenation
- Determination of absolute configuration
- Determination of optical purity
- Optical resolution
- Ring closure of aminocarboxylic acids
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