Oxazepines and thiazepines 32. Synthesis of tetracyclic benzothiazepines

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Abstract

Tetracyclic benzothiazepines 24-41 have been synthesized either by the reaction of 2-aminothiophenol with α,β-enones 1-18 in hot toluene in the presence of trifluoroacetic acid or by the ring closure of compounds 19-23 in a mixture of boiling ethanol and acetic acid. Structure of the synthesized compounds 19-41 have been elucidated by IR and 1H-NMR spectroscopies.

Original languageEnglish
Pages (from-to)523-530
Number of pages8
JournalScientia Pharmaceutica
Volume64
Issue number3-4
Publication statusPublished - Sep 12 1996

Keywords

  • 2-arylidene-1-benzosu berones
  • 2-arylidene-1-indanones
  • 2-arylidene-1-tetralones
  • benzothiazepines

ASJC Scopus subject areas

  • Pharmaceutical Science

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