Oxamides as novel NR2B selective NMDA receptor antagonists

Gizella Barta-Szalai, István Borza, Éva Bozó, Csilla Kiss, Béla Ágai, Ágnes Proszenyák, György M. Keseru, Anikó Gere, Sándor Kolok, Kornél Galgóczy, Csilla Horváth, Sándor Farkas, György Domány

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.

Original languageEnglish
Pages (from-to)3953-3956
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number15
DOIs
Publication statusPublished - Aug 2 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Barta-Szalai, G., Borza, I., Bozó, É., Kiss, C., Ágai, B., Proszenyák, Á., Keseru, G. M., Gere, A., Kolok, S., Galgóczy, K., Horváth, C., Farkas, S., & Domány, G. (2004). Oxamides as novel NR2B selective NMDA receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 14(15), 3953-3956. https://doi.org/10.1016/j.bmcl.2004.05.053