Gonadotropin releasing hormone loading test has a great role in determination of hypophyseal hormonal response in anovulatory conditions. Ten anovulatory patients were selected using gonadotropin releasing hormone loading test. In ten selected cases the rise in the FSH and LH levels was 1.5-2.0-fold and 6-fold respectively. In early follicular phase ovulation induction was carried out with pure FSH given intramuscularly between 3 and 8 days of the cycle in a daily dose 150 IU for starting of follicular maturation. After that in middle and late proliferation phase ovulation induction was continued by pulsatile gonadotropin releasing hormone treatment subcutaneously in a dose 20 μg every 90 minutes. During the treatment the plasma FSH, LH, oestradiol and progesteron levels were measured and ultrasound folliculometry was performed. Of the 12 treated cycles all were ovulatory and 4 pregnancies occurred. Hyperstimulation was not found. Our data demonstrated that the combination of intramuscularly administered pure FSH and pulsatile subcutaneous administration of GnRH is a successful treatment modality in selected cases of anovulatory patients.
|Translated title of the contribution||Ovulation induction by administration of pure FSH and pulsatile gonadotropin releasing hormone in selected cases|
|Number of pages||3|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jan 1 1995|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology