Overview of large animal myocardial infarction models (review)

E. Lukács, B. Magyari, L. Tóth, Zs Petrási, I. Repa, A. Koller, I. Horváth

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

There are several experimental models for the in vivo investigation of myocardial infarction (MI) in small (mouse, rat) and large animals (dog, pig, sheep and baboons). The application of large animal models raises ethical concerns, the design of experiments needs longer follow-up times, requiring proper breeding and housing conditions, therefore resulting in higher cost, than in vitro or small animal studies. On the other hand, the relevance of large animal models is very important, since they mostly resemble to human physiological and pathophysiological processes. The first main difference among MI models is the method of induction (open or closed chest, e.g. surgical or catheter based); the second main difference is the presence or absence of reperfusion. The former (i.e. reperfused MI) allows the investigation of reperfusion injury and new catheter based techniques during percutaneous coronary interventions, while the latter (i.e. nonreperfused MI) serves as a traditional coronary occlusion model, to test the effects of new pharmacological agents and biological therapies, as cell therapy. The reperfused and nonreperfused myocardial infarction has different outcomes, regarding left ventricular function, remodelling, subsequent heart failure, aneurysm formation and mortality. Our aim was to review the literature and report our findings regarding experimental MI models, regarding the differences among species, methods, reproducibility and interpretation.

Original languageEnglish
Pages (from-to)365-381
Number of pages17
JournalActa Physiologica Hungarica
Volume99
Issue number4
DOIs
Publication statusPublished - Dec 1 2012

Fingerprint

Myocardial Infarction
Catheters
Animal Models
Heart Aneurysm
Physiological Phenomena
Biological Therapy
Ventricular Remodeling
Papio
Coronary Occlusion
Percutaneous Coronary Intervention
Cell- and Tissue-Based Therapy
Reperfusion Injury
Left Ventricular Function
Reperfusion
Breeding
Sheep
Theoretical Models
Swine
Thorax
Heart Failure

Keywords

  • design
  • experimental models
  • myocardial infarction
  • relevance
  • reperfusion injury

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

Overview of large animal myocardial infarction models (review). / Lukács, E.; Magyari, B.; Tóth, L.; Petrási, Zs; Repa, I.; Koller, A.; Horváth, I.

In: Acta Physiologica Hungarica, Vol. 99, No. 4, 01.12.2012, p. 365-381.

Research output: Contribution to journalArticle

Lukács, E. ; Magyari, B. ; Tóth, L. ; Petrási, Zs ; Repa, I. ; Koller, A. ; Horváth, I. / Overview of large animal myocardial infarction models (review). In: Acta Physiologica Hungarica. 2012 ; Vol. 99, No. 4. pp. 365-381.
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