Overnight Changes in Lung Function of Obese Patients with Obstructive Sleep Apnoea

Laszlo Kunos, Zsofia Lazar, Fruzsina Martinovszky, Adam D. Tarnoki, David L. Tarnoki, Daniel Kovacs, Bianka Forgo, P. Horváth, Gyorgy Losonczy, Andras Bikov

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: Obstructive sleep apnoea (OSA) is a prevalent disorder, characterised by collapse of the upper airways during sleep. The impact of sleep-disordered breathing on pulmonary function indices is however currently not well described. The aim of the study was to evaluate diurnal change in lung function indices in a cohort of patients with OSA and relate pulmonary function changes to disease severity. Methods: 42 patients with OSA and 73 healthy control subjects participated in the study. Asthma and COPD were excluded in all volunteers following a clinical and spirometric assessment. Spirometry was then performed in all subjects in the evening and the morning following a polysomnography study. Results: There was no difference in evening or morning FEV1 or FVC between patients and control subjects (p > 0.05). Neither FEV1 nor FVC changed in control subjects overnight (p > 0.05). In contrast, FEV1 significantly increased from evening (2.18/1.54–4.46/L) to morning measurement (2.26/1.42–4.63/L) in OSA without any change in FVC. The FEV1 increase in OSA was related to male gender, obesity and the lack of treatment with statins or β-blockers (all p < 0.05). A tendency for a direct correlation was apparent between overnight FEV1 change and RDI (p = 0.05, r = 0.30). Conclusions: Diurnal variations in spirometric indices occur in patients with OSA and FEV1 appears to increase in subjects with OSA overnight. These changes occur in the absence of change in FVC and are directly related to the severity of OSA. These findings dictate a need to consider time of lung function measurement.

Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalLung
Volume195
Issue number1
DOIs
Publication statusPublished - Feb 1 2017

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Obstructive Sleep Apnea
Lung
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Polysomnography
Spirometry
Sleep Apnea Syndromes
Chronic Obstructive Pulmonary Disease
Volunteers
Healthy Volunteers
Sleep
Asthma
Obesity

Keywords

  • Forced expiratory volume in 1 s
  • Lung function
  • Obstructive sleep apnoea
  • Overnight changes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Kunos, L., Lazar, Z., Martinovszky, F., Tarnoki, A. D., Tarnoki, D. L., Kovacs, D., ... Bikov, A. (2017). Overnight Changes in Lung Function of Obese Patients with Obstructive Sleep Apnoea. Lung, 195(1), 127-133. https://doi.org/10.1007/s00408-016-9957-1

Overnight Changes in Lung Function of Obese Patients with Obstructive Sleep Apnoea. / Kunos, Laszlo; Lazar, Zsofia; Martinovszky, Fruzsina; Tarnoki, Adam D.; Tarnoki, David L.; Kovacs, Daniel; Forgo, Bianka; Horváth, P.; Losonczy, Gyorgy; Bikov, Andras.

In: Lung, Vol. 195, No. 1, 01.02.2017, p. 127-133.

Research output: Contribution to journalArticle

Kunos, L, Lazar, Z, Martinovszky, F, Tarnoki, AD, Tarnoki, DL, Kovacs, D, Forgo, B, Horváth, P, Losonczy, G & Bikov, A 2017, 'Overnight Changes in Lung Function of Obese Patients with Obstructive Sleep Apnoea', Lung, vol. 195, no. 1, pp. 127-133. https://doi.org/10.1007/s00408-016-9957-1
Kunos L, Lazar Z, Martinovszky F, Tarnoki AD, Tarnoki DL, Kovacs D et al. Overnight Changes in Lung Function of Obese Patients with Obstructive Sleep Apnoea. Lung. 2017 Feb 1;195(1):127-133. https://doi.org/10.1007/s00408-016-9957-1
Kunos, Laszlo ; Lazar, Zsofia ; Martinovszky, Fruzsina ; Tarnoki, Adam D. ; Tarnoki, David L. ; Kovacs, Daniel ; Forgo, Bianka ; Horváth, P. ; Losonczy, Gyorgy ; Bikov, Andras. / Overnight Changes in Lung Function of Obese Patients with Obstructive Sleep Apnoea. In: Lung. 2017 ; Vol. 195, No. 1. pp. 127-133.
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AU - Tarnoki, David L.

AU - Kovacs, Daniel

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N2 - Purpose: Obstructive sleep apnoea (OSA) is a prevalent disorder, characterised by collapse of the upper airways during sleep. The impact of sleep-disordered breathing on pulmonary function indices is however currently not well described. The aim of the study was to evaluate diurnal change in lung function indices in a cohort of patients with OSA and relate pulmonary function changes to disease severity. Methods: 42 patients with OSA and 73 healthy control subjects participated in the study. Asthma and COPD were excluded in all volunteers following a clinical and spirometric assessment. Spirometry was then performed in all subjects in the evening and the morning following a polysomnography study. Results: There was no difference in evening or morning FEV1 or FVC between patients and control subjects (p > 0.05). Neither FEV1 nor FVC changed in control subjects overnight (p > 0.05). In contrast, FEV1 significantly increased from evening (2.18/1.54–4.46/L) to morning measurement (2.26/1.42–4.63/L) in OSA without any change in FVC. The FEV1 increase in OSA was related to male gender, obesity and the lack of treatment with statins or β-blockers (all p < 0.05). A tendency for a direct correlation was apparent between overnight FEV1 change and RDI (p = 0.05, r = 0.30). Conclusions: Diurnal variations in spirometric indices occur in patients with OSA and FEV1 appears to increase in subjects with OSA overnight. These changes occur in the absence of change in FVC and are directly related to the severity of OSA. These findings dictate a need to consider time of lung function measurement.

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