Overlapping protective and destructive regulatory pathways in apical periodontitis

Research output: Contribution to journalReview article

66 Citations (Scopus)


Introduction Protective and destructive immunoreactions take place simultaneously in apical periodontitis. However, the same reactions defending the periapical area from infection-derived damage may also result in host tissue injury. Methods The inflammatory reaction of the periapical tissues is self-limited. Regeneration of the injured tooth-supporting structures may follow elimination of the causative microbial irritation. Results Recent experimental and clinical observations have identified important interplay between positive and negative regulatory pathways. A network of stimulatory and inhibitory feedback loops may influence the intensity of the defense and inflammatory responses and the balance between bone resorption and regeneration, resulting in lesion expansion or healing of apical periodontitis. Conclusions We critically discuss research data on regulatory mechanisms that control the activity of host effector cells and signaling molecules during interactions with pathogenic microbes.

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalJournal of Endodontics
Issue number2
Publication statusPublished - Feb 1 2014


  • Apical periodontitis
  • bone resorption
  • cytokines
  • immunity
  • inflammation
  • stem cells

ASJC Scopus subject areas

  • Dentistry(all)

Fingerprint Dive into the research topics of 'Overlapping protective and destructive regulatory pathways in apical periodontitis'. Together they form a unique fingerprint.

  • Cite this