Overlapping juvenile idiopathic arthritis and systemic lupus erythematosus

A case report

Anna Bazsó, Krisztina Sevcic, Ilonka Orbán, G. Poór, Z. Balogh, E. Kiss

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hereby, we report the case of a 12-year-old girl developing oligoarthritis and progressing into a polyarticular form. Rheumatoid factor was positive, and juvenile idiopathic arthritis (JIA) was diagnosed. After a poor response to DMARDs, an anti-TNF agent (infliximab) was initiated, but to be discontinued due to an allergic reaction. The same complication was observed with the fully human derivative, adalimumab. At the age of 22, the patient presented septicemia with severe anemia and subsequent development of leukopenia, myocarditis with heart failure, and ANA, aSm, aSS-A, aCL positives, and nephrotic syndrome. These new clinical manifestations fulfilled the classification criteria for the diagnosis of systemic lupus erythematosus. Due to the poor therapeutic responses for both diseases, alternative medical options have to be considered, such as targeted therapy with anti-CD20 or interleukin-6 receptor antagonist monoclonal antibodies. This patient may also be a candidate for autologous hemopoietic stem cell transplantation.

Original languageEnglish
Pages (from-to)695-698
Number of pages4
JournalRheumatology International
Volume31
Issue number5
DOIs
Publication statusPublished - May 2011

Fingerprint

Juvenile Arthritis
Systemic Lupus Erythematosus
Interleukin-6 Receptors
Antirheumatic Agents
Rheumatoid Factor
Myocarditis
Leukopenia
Nephrotic Syndrome
Stem Cell Transplantation
Anemia
Sepsis
Hypersensitivity
Heart Failure
Monoclonal Antibodies
Therapeutics
Infliximab
Adalimumab

Keywords

  • JIA-SLE overlap
  • Targeted therapy

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Overlapping juvenile idiopathic arthritis and systemic lupus erythematosus : A case report. / Bazsó, Anna; Sevcic, Krisztina; Orbán, Ilonka; Poór, G.; Balogh, Z.; Kiss, E.

In: Rheumatology International, Vol. 31, No. 5, 05.2011, p. 695-698.

Research output: Contribution to journalArticle

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