Overlap of coronary disease and pulmonary arterial hypertension in systemic sclerosis

A. Komócsi, T. Pintér, R. Faludi, B. Magyari, J. Bozó, G. Kumánovics, T. Minier, J. Radics, L. Czirják

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives: Pulmonary arterial hypertension (PAH) is a common complication of systemic sclerosis (SSc). Symptoms of coronary artery disease (CAD) and PAH are closely related and cardiac catheterisation is needed to confirm their diagnosis. The aim of the present work was to investigate of the extent of overlap between CAD and PAH in patients with SSc. Methods: Based on non-invasive investigations, 20 patients out of 120 were suspected to have PAH ("suspected PAH" group). Another 10 patients showed signs of coronary disease ("suspected CAD" Group). In these 30 patients, right heart catheterisation and coronary angiography were performed, and the coronary flow reserve (CFR) was assessed by thermodilution technique. Results: In the "suspected PAH" and the "suspected CAD" groups, PAH was found in 12/20 and 2/10 cases, and coronary artery stenosis in 9/20 and 6/10 cases, respectively. Severely reduced CFR was revealed in 7/20 and 3/10 cases, respectively. Conclusions: PAH, CAD and reduced CFR all show a considerable overlap in symptomatic patients with SSc. The current non-invasive investigations are neither sensitive nor specific enough to make an appropriate distinction between these different disease manifestations. A more invasive approach, such as coronary angiography at the initial catheterisation, is required to properly characterise and treat the different forms of cardiac involvement in SSc.

Original languageEnglish
Pages (from-to)202-205
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume69
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Systemic Scleroderma
Pulmonary Hypertension
Coronary Disease
Coronary Artery Disease
Angiography
Cardiac Catheterization
Coronary Angiography
Thermodilution
Coronary Stenosis
Patient Rights
Catheterization

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

Cite this

Overlap of coronary disease and pulmonary arterial hypertension in systemic sclerosis. / Komócsi, A.; Pintér, T.; Faludi, R.; Magyari, B.; Bozó, J.; Kumánovics, G.; Minier, T.; Radics, J.; Czirják, L.

In: Annals of the Rheumatic Diseases, Vol. 69, No. 1, 01.2010, p. 202-205.

Research output: Contribution to journalArticle

Komócsi, A, Pintér, T, Faludi, R, Magyari, B, Bozó, J, Kumánovics, G, Minier, T, Radics, J & Czirják, L 2010, 'Overlap of coronary disease and pulmonary arterial hypertension in systemic sclerosis', Annals of the Rheumatic Diseases, vol. 69, no. 1, pp. 202-205. https://doi.org/10.1136/ard.2008.096255
Komócsi, A. ; Pintér, T. ; Faludi, R. ; Magyari, B. ; Bozó, J. ; Kumánovics, G. ; Minier, T. ; Radics, J. ; Czirják, L. / Overlap of coronary disease and pulmonary arterial hypertension in systemic sclerosis. In: Annals of the Rheumatic Diseases. 2010 ; Vol. 69, No. 1. pp. 202-205.
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