A meddo férfiak spermiumainak citogenetikai vizsgálata elso hazai tapasztalatok

Translated title of the contribution: Our first experiences with cytogenetic investigations of sperms at infertile males

András Tóth, Erika P. Tardy, Anna Kékesi, Sándor Drávucz, Zoltán Murányi, Miklós Vajda, István Dévai, Imre Cseh, Edit Erdei

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The purpose of this study was to analyze the rate of numerical chromosomal anomalies in sperm nuclei. Nine infertile patients and 25 control donors were evaluated for chromsomes 16, 18, X and Y. The infertile patients had normal karyotype but abnormal semen parameters. The mean rate of disomies was significantly higher in infertile males. In conclusion, patients with teratozoospermia or oligo-astheno-teratozoospermia may have an increased rate of sperm aneuploidy therefore a higher risk of producing genetically abnormal embryos. These findings suggest the necessity of genetic counselling before assisted reproductive techniques. Those patients who have high rate of chromosomal anomalies in sperms preimplantation or prenatal diagnosis should be considered. Future studies are needed to examine the aneuploidy rate for many of the remaining chromosomes and to decide the relationship between clinical phenotype and aneuploid frequency in sperm nuclei.

Translated title of the contributionOur first experiences with cytogenetic investigations of sperms at infertile males
Original languageHungarian
Pages (from-to)143-147
Number of pages5
JournalMagyar Noorvosok Lapja
Volume66
Issue number3
Publication statusPublished - Jan 1 2003

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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  • Cite this

    Tóth, A., Tardy, E. P., Kékesi, A., Drávucz, S., Murányi, Z., Vajda, M., Dévai, I., Cseh, I., & Erdei, E. (2003). A meddo férfiak spermiumainak citogenetikai vizsgálata elso hazai tapasztalatok. Magyar Noorvosok Lapja, 66(3), 143-147.