The authors performed 1149 chorionic villi samplings (CVS) between 1994 and 1999. First they have used the transcervical approach, followed by the transabdominal, since 1994. Their data were analized regarding the indications, the 'side effects and the clinical outcome of the CVS. Vast majority of the CVS' (91,6%) was done for cytogenetic evaluation of the fetus, but during the recent few years number of the molecular diagnoses has also increased (7,6%). Advanced maternal age was the most common indication for fetal karyotyping, although it is remarkable, that the number of CVS-s done on the basis of suspicious ultrasonographic findings has increased substantially during the past 5-6 years. Abnormal fetal karyotype is more frequent in this group (14%), as compared to CVS-s done for other indications. These data underline the importance of the second trimester ultrasound sreening. Either the frequency of the side effects or the fetal loss rate were lower after transabdominal CVS as compared to that of the transcervical CVS (1.7% and 4.8%, respectively). 74,1% of all the cases ended up with birth after completion of the 37th week of gestation. The rate of premature births did not exceed the Hungarian average figures. The results obtained support the conclusion: CVS is a safe method for prenatal diagnosis at any trimester of pregnancy.
|Number of pages||12|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jan 1 2003|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology