Otosclerosis: An autoimmune disease?

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives: To review our current knowledge of the etiopathogenesis of otosclerotic bone remodeling including genetics, viral infection, autoimmunity and inflammation and to discuss disease pathogenesis with relevance for pharmacotherapy. Systematic review methodology: Relevant publications on the etiopathogenesis, molecular biology, genetics and histopathology of otosclerosis from 1984 to 2009 were analyzed. Results and conclusions: Otosclerosis is a bone remodeling disorder of the human otic capsule, however, the etiopathogenesis remains unclear. Genetic predisposition, disturbed bone metabolism, persistent measles virus infection, autoimmunity, hormonal and environmental factors also may play contributing roles in the pathogenesis of otosclerosis. Since, diagnosis of otosclerosis is still based on histopathological examination of the removed stapes footplate, systemic prospective studies based on comprehensive histopathological and molecular biological analysis are necessary to get further information about the background of disease.

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalAutoimmunity Reviews
Volume9
Issue number2
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Otosclerosis
Autoimmune Diseases
Bone Remodeling
Virus Diseases
Autoimmunity
Molecular Biology
Stapes
Measles virus
Genetic Predisposition to Disease
Capsules
Ear
Publications
Prospective Studies
Inflammation
Bone and Bones
Drug Therapy

Keywords

  • Autoimmunity
  • Epidemiology
  • Etiopathogenesis
  • Genetics
  • Inflammation
  • Measles virus
  • Otosclerosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Otosclerosis : An autoimmune disease? / Karosi, T.; Szekanecz, Z.; Sziklai, I.

In: Autoimmunity Reviews, Vol. 9, No. 2, 12.2009, p. 95-101.

Research output: Contribution to journalArticle

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