Otoacoustic emission in myasthenia gravis patients and the role of efferent activation

L. Tóth, Tamás Rácz, Péter Diószeghy, G. Répássy, István Lampé

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We performed transient evoked otoacoustic emission (TEOAE) measurements on 29 ears of myasthenia gravis (MG) patients. The purpose of the study was to support the role of acetylcholine (ACh) in the efferent innervation of cochlear outer hair cells (OHCs). Another aim was to establish additional diagnostic tools for the early determination of MG. Initially, threshold audiometry and impedance measurements showed normal values on the ears examined. The main finding was that TEOAE values were significantly lower in MG patients than in healthy controls. Mestinon, a reversible cholinesterase inhibitor, resulted in a significant increase in mean values of TEOAEs, although these values were still lower than normal. The results suggest that in MG, acetylcholine receptor (AChR) autoantibodies inhibit the function of OHC AChRs. Thus, the TEOAE generated by the active movements of OHCs is decreased in MG. Mestinon prevents the degradation of ACh, and thus stimulates efferent function and increases TEOAE values. The results obtained in this study support the role of ACh in the efferent function of OHC, as well as the impaired function of hair cell AChRs in MG patients. Consequently, measuring TEOAEs may be useful in the early: diagnosis of some forms of MG. These results reinforce the importance of collaboration between neurologists and otolaryngologists in the management of diseases with pathological neurotransmission.

Original languageEnglish
Pages (from-to)123-125
Number of pages3
JournalHearing Research
Volume126
Issue number1-2
DOIs
Publication statusPublished - Dec 1998

Fingerprint

Outer Auditory Hair Cells
Myasthenia Gravis
Pyridostigmine Bromide
Acetylcholine
Ear
Acoustic Impedance Tests
Cholinesterase Inhibitors
Cholinergic Receptors
Disease Management
Synaptic Transmission
Autoantibodies
Early Diagnosis
Reference Values

Keywords

  • Acetylcholine receptor
  • Myasthenia gravis
  • Transient evoked otoacoustic emission

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Otoacoustic emission in myasthenia gravis patients and the role of efferent activation. / Tóth, L.; Rácz, Tamás; Diószeghy, Péter; Répássy, G.; Lampé, István.

In: Hearing Research, Vol. 126, No. 1-2, 12.1998, p. 123-125.

Research output: Contribution to journalArticle

Tóth, L. ; Rácz, Tamás ; Diószeghy, Péter ; Répássy, G. ; Lampé, István. / Otoacoustic emission in myasthenia gravis patients and the role of efferent activation. In: Hearing Research. 1998 ; Vol. 126, No. 1-2. pp. 123-125.
@article{90ff81696fb44cbc9f688ee56eaaac3b,
title = "Otoacoustic emission in myasthenia gravis patients and the role of efferent activation",
abstract = "We performed transient evoked otoacoustic emission (TEOAE) measurements on 29 ears of myasthenia gravis (MG) patients. The purpose of the study was to support the role of acetylcholine (ACh) in the efferent innervation of cochlear outer hair cells (OHCs). Another aim was to establish additional diagnostic tools for the early determination of MG. Initially, threshold audiometry and impedance measurements showed normal values on the ears examined. The main finding was that TEOAE values were significantly lower in MG patients than in healthy controls. Mestinon, a reversible cholinesterase inhibitor, resulted in a significant increase in mean values of TEOAEs, although these values were still lower than normal. The results suggest that in MG, acetylcholine receptor (AChR) autoantibodies inhibit the function of OHC AChRs. Thus, the TEOAE generated by the active movements of OHCs is decreased in MG. Mestinon prevents the degradation of ACh, and thus stimulates efferent function and increases TEOAE values. The results obtained in this study support the role of ACh in the efferent function of OHC, as well as the impaired function of hair cell AChRs in MG patients. Consequently, measuring TEOAEs may be useful in the early: diagnosis of some forms of MG. These results reinforce the importance of collaboration between neurologists and otolaryngologists in the management of diseases with pathological neurotransmission.",
keywords = "Acetylcholine receptor, Myasthenia gravis, Transient evoked otoacoustic emission",
author = "L. T{\'o}th and Tam{\'a}s R{\'a}cz and P{\'e}ter Di{\'o}szeghy and G. R{\'e}p{\'a}ssy and Istv{\'a}n Lamp{\'e}",
year = "1998",
month = "12",
doi = "10.1016/S0378-5955(98)00154-3",
language = "English",
volume = "126",
pages = "123--125",
journal = "Hearing Research",
issn = "0378-5955",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Otoacoustic emission in myasthenia gravis patients and the role of efferent activation

AU - Tóth, L.

AU - Rácz, Tamás

AU - Diószeghy, Péter

AU - Répássy, G.

AU - Lampé, István

PY - 1998/12

Y1 - 1998/12

N2 - We performed transient evoked otoacoustic emission (TEOAE) measurements on 29 ears of myasthenia gravis (MG) patients. The purpose of the study was to support the role of acetylcholine (ACh) in the efferent innervation of cochlear outer hair cells (OHCs). Another aim was to establish additional diagnostic tools for the early determination of MG. Initially, threshold audiometry and impedance measurements showed normal values on the ears examined. The main finding was that TEOAE values were significantly lower in MG patients than in healthy controls. Mestinon, a reversible cholinesterase inhibitor, resulted in a significant increase in mean values of TEOAEs, although these values were still lower than normal. The results suggest that in MG, acetylcholine receptor (AChR) autoantibodies inhibit the function of OHC AChRs. Thus, the TEOAE generated by the active movements of OHCs is decreased in MG. Mestinon prevents the degradation of ACh, and thus stimulates efferent function and increases TEOAE values. The results obtained in this study support the role of ACh in the efferent function of OHC, as well as the impaired function of hair cell AChRs in MG patients. Consequently, measuring TEOAEs may be useful in the early: diagnosis of some forms of MG. These results reinforce the importance of collaboration between neurologists and otolaryngologists in the management of diseases with pathological neurotransmission.

AB - We performed transient evoked otoacoustic emission (TEOAE) measurements on 29 ears of myasthenia gravis (MG) patients. The purpose of the study was to support the role of acetylcholine (ACh) in the efferent innervation of cochlear outer hair cells (OHCs). Another aim was to establish additional diagnostic tools for the early determination of MG. Initially, threshold audiometry and impedance measurements showed normal values on the ears examined. The main finding was that TEOAE values were significantly lower in MG patients than in healthy controls. Mestinon, a reversible cholinesterase inhibitor, resulted in a significant increase in mean values of TEOAEs, although these values were still lower than normal. The results suggest that in MG, acetylcholine receptor (AChR) autoantibodies inhibit the function of OHC AChRs. Thus, the TEOAE generated by the active movements of OHCs is decreased in MG. Mestinon prevents the degradation of ACh, and thus stimulates efferent function and increases TEOAE values. The results obtained in this study support the role of ACh in the efferent function of OHC, as well as the impaired function of hair cell AChRs in MG patients. Consequently, measuring TEOAEs may be useful in the early: diagnosis of some forms of MG. These results reinforce the importance of collaboration between neurologists and otolaryngologists in the management of diseases with pathological neurotransmission.

KW - Acetylcholine receptor

KW - Myasthenia gravis

KW - Transient evoked otoacoustic emission

UR - http://www.scopus.com/inward/record.url?scp=0032408444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032408444&partnerID=8YFLogxK

U2 - 10.1016/S0378-5955(98)00154-3

DO - 10.1016/S0378-5955(98)00154-3

M3 - Article

C2 - 9872140

AN - SCOPUS:0032408444

VL - 126

SP - 123

EP - 125

JO - Hearing Research

JF - Hearing Research

SN - 0378-5955

IS - 1-2

ER -