Osteoclastogenesis Regulation Metabolites from the Coral-Associated Fungus Pseudallescheria boydii TW-1024-3

Da Hua Liu, Yi Zhe Sun, T. Kurtán, Attila Mándi, Hua Tang, Jiao Li, Li Su, Chun Lin Zhuang, Zhi Yong Liu, Wen Zhang

Research output: Contribution to journalArticle

Abstract

Three new compounds (9-11) were isolated together with eight known analogues from the fungus Pseudallescheria boydii associated with the South China Sea soft coral Sinularia sandensis. The structures of the new compounds were elucidated on the basis of the spectroscopic analysis, and the absolute configurations including the sulfur stereogenic center of a sulfoxide moiety were determined by comparison of experimental ECD spectra to TDDFT/ECD calculations. Epimeric chiral sulfoxides differing in the absolute configuration of the sulfur chirality center could be efficiently distinguished and assigned by comparing the experimental ECD to those of calculations for the sulfur epimers. In the in vitro biotests for osteoclastogenesis effects, compounds 1, 5, 7, and 10 exhibited a stimulatory activity, while compound 3 displayed an inhibitory activity.

Original languageEnglish
JournalJournal of Natural Products
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Pseudallescheria
Anthozoa
Metabolites
Fungi
Sulfur
Osteogenesis
sulfoxide
Sulfoxides
Spectroscopic analysis
Chirality
Oceans and Seas
China

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Osteoclastogenesis Regulation Metabolites from the Coral-Associated Fungus Pseudallescheria boydii TW-1024-3. / Liu, Da Hua; Sun, Yi Zhe; Kurtán, T.; Mándi, Attila; Tang, Hua; Li, Jiao; Su, Li; Zhuang, Chun Lin; Liu, Zhi Yong; Zhang, Wen.

In: Journal of Natural Products, 01.01.2019.

Research output: Contribution to journalArticle

Liu, Da Hua ; Sun, Yi Zhe ; Kurtán, T. ; Mándi, Attila ; Tang, Hua ; Li, Jiao ; Su, Li ; Zhuang, Chun Lin ; Liu, Zhi Yong ; Zhang, Wen. / Osteoclastogenesis Regulation Metabolites from the Coral-Associated Fungus Pseudallescheria boydii TW-1024-3. In: Journal of Natural Products. 2019.
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AU - Tang, Hua

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AU - Zhuang, Chun Lin

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