Plasma cortisol concentration was determined in blood samples obtained in six newborns during echange transfusion at 3-5 minute intervals. A radiotransin-assay using horse serum as a binding protein and toluene-based scintillation fluid for separation of unbound tracer proved to be a relatively specific method for determination of cortisol level in the plasma of newborns. Irregular oscillations were observed in four newborns, whereas a single peak could be demonstrated in two cases during the 40-70 minute period observed. The results suggest that the CRF-ACTH-cortisol secretion may already be episodic in the newborn period.
|Number of pages||6|
|Publication status||Published - Dec 1 1980|
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