Orthostatic stimuli rapidly change plasma adrenomedullin in humans

Andreas Rössler, Z. László, Bernd Haditsch, Helmut G. Hinghofer-Szalkay

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The aim of this study was to evaluate the effect of orthostasis on the time course of plasma adrenomedullin concentration. On 5 different days, normotensive subjects were randomized to undergo for 30 minutes either 12°, 30°, 53°, or 70°passive head-up tilt or to remain supine. Venous blood was collected from each subject in the supine position before tilting, at 3 and 27 minutes during tilting, and at 2 and 50 minutes after orthostasis. Plasma adrenomedullin increased significantly with tilt of ≥30°in a stimulus- dependent manner. Approximately half of the increase seen at 27 minutes occurred during the first 2 minutes of upright positioning; the maximum effect with 70°tilt was +70%. Elevations in norepinephrine, epinephrine, aldosterone, plasma renin activity, vasopressin, heart rate, and mean arterial pressure were also significant. Hematocrit, blood density, plasma density, and plasma volume loss rose (P

Original languageEnglish
Pages (from-to)1147-1151
Number of pages5
JournalHypertension
Volume34
Issue number5
Publication statusPublished - Nov 1999

Fingerprint

Adrenomedullin
Dizziness
Plasma Volume
Supine Position
Aldosterone
Vasopressins
Hematocrit
Renin
Epinephrine
Norepinephrine
Arterial Pressure
Heart Rate
Head
human ADM protein

Keywords

  • Adrenomedullin
  • Barorereflex
  • Catecholamines
  • Tilt, head-up
  • Volume, plasma

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Rössler, A., László, Z., Haditsch, B., & Hinghofer-Szalkay, H. G. (1999). Orthostatic stimuli rapidly change plasma adrenomedullin in humans. Hypertension, 34(5), 1147-1151.

Orthostatic stimuli rapidly change plasma adrenomedullin in humans. / Rössler, Andreas; László, Z.; Haditsch, Bernd; Hinghofer-Szalkay, Helmut G.

In: Hypertension, Vol. 34, No. 5, 11.1999, p. 1147-1151.

Research output: Contribution to journalArticle

Rössler, A, László, Z, Haditsch, B & Hinghofer-Szalkay, HG 1999, 'Orthostatic stimuli rapidly change plasma adrenomedullin in humans', Hypertension, vol. 34, no. 5, pp. 1147-1151.
Rössler A, László Z, Haditsch B, Hinghofer-Szalkay HG. Orthostatic stimuli rapidly change plasma adrenomedullin in humans. Hypertension. 1999 Nov;34(5):1147-1151.
Rössler, Andreas ; László, Z. ; Haditsch, Bernd ; Hinghofer-Szalkay, Helmut G. / Orthostatic stimuli rapidly change plasma adrenomedullin in humans. In: Hypertension. 1999 ; Vol. 34, No. 5. pp. 1147-1151.
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