Orthostatic stimuli rapidly change plasma adrenomedullin in humans

Andreas Rössler, Zoltán László, Bernd Haditsch, Helmut G. Hinghofer-Szalkay

Research output: Contribution to journalArticle

42 Citations (Scopus)


The aim of this study was to evaluate the effect of orthostasis on the time course of plasma adrenomedullin concentration. On 5 different days, normotensive subjects were randomized to undergo for 30 minutes either 12°, 30°, 53°, or 70°passive head-up tilt or to remain supine. Venous blood was collected from each subject in the supine position before tilting, at 3 and 27 minutes during tilting, and at 2 and 50 minutes after orthostasis. Plasma adrenomedullin increased significantly with tilt of ≥30°in a stimulus- dependent manner. Approximately half of the increase seen at 27 minutes occurred during the first 2 minutes of upright positioning; the maximum effect with 70°tilt was +70%. Elevations in norepinephrine, epinephrine, aldosterone, plasma renin activity, vasopressin, heart rate, and mean arterial pressure were also significant. Hematocrit, blood density, plasma density, and plasma volume loss rose (P<0.05) at 53°and 70°tilt. Our results indicate that adrenomedullin may play an important role in stabilization of hemodynamics during passive orthostasis. In conclusion, plasma adrenomedullin rapidly increases with orthostatic challenge in a stimulus-dependent manner and also swiftly returns to baseline levels after the subject resumes the supine position.

Original languageEnglish
Pages (from-to)1147-1151
Number of pages5
Issue number5
Publication statusPublished - Nov 1999


  • Adrenomedullin
  • Barorereflex
  • Catecholamines
  • Tilt, head-up
  • Volume, plasma

ASJC Scopus subject areas

  • Internal Medicine

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