Original Communication Beneficial vascular and metabolic effects of cobalt-ATP in spontaneously hypertensive rabbits with diffuse chronic cerebral ischaemia

Katalin Hegedüs, I. Fekete, László Molnár

Research output: Contribution to journalArticle

Abstract

The in vivo effects of adenosine triphosphate (ATP) have not been investigated in cerebrovascular diseases. The use of the long-acting cobalt-ATP complex (Co-ATP) permits us to observe the effects of ATP without the influence of its metabolites. This study was designed to compare the effects of intravenous Co-ATP on the cerebral blood flow (CBF), polarographically detected oxygen currents (O2a), mean arterial blood pressure (MABP), heart rate, respiration rate, cerebral electrical activity, arterial blood gases, pH, and glucose in 13 normotensive (NT) rabbits to those in 14 stroke-prone spontaneously hypertensive (HT) animals. CBF was measured by the hydrogen and heat clearance methods. In response to Co-ATP, MABP decreased and CBF increased significantly in both groups. The decrease in MABP was more marked in HT rabbits, while CBF response was 25% smaller than in NT animals. The ratio of O2a to CBF diminished moderately and simultaneously with the CBF increase in NT rabbits. In HT rabbits, the decrease in O2a/CBF was larger and began when CBF response reached its maximum. We suggest that despite the restricted CBF response, long-acting ATP should still be taken into consideration as a supplementary treatment of hypertensive encephalopathy because of its beneficial effects on cerebral metabolism and hypertension.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalJournal of Neurology
Volume242
Issue number4
DOIs
Publication statusPublished - Apr 1995

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Cerebrovascular Circulation
Cobalt
Brain Ischemia
Blood Vessels
Adenosine Triphosphate
Communication
Rabbits
Arterial Pressure
Hypertensive Encephalopathy
Cerebrovascular Disorders
Respiratory Rate
Hydrogen
Hot Temperature
Heart Rate
Gases

Keywords

  • Adenosine triphosphate
  • Cerebral ischaemia Metabolism
  • Hypertension
  • Rabbit

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Original Communication Beneficial vascular and metabolic effects of cobalt-ATP in spontaneously hypertensive rabbits with diffuse chronic cerebral ischaemia. / Hegedüs, Katalin; Fekete, I.; Molnár, László.

In: Journal of Neurology, Vol. 242, No. 4, 04.1995, p. 243-248.

Research output: Contribution to journalArticle

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