Origin of the nerve endings in the surface zone of the median eminence of the rat hypothalamus

M. Réthelyi, B. Halász

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In order to study the origin of the nerve endings in the surface zone (zona palisadica) of the median eminence and the proximal part of the pituitary stalk, experiments were designed to determine the extent of the smallest region of the brain, isolation of which does not result in terminal degeneration in this zone. Various hypothalamic areas were partially or totally separated from the brain by means of a stereotaxically manipulated bayonet-shape knife and the zona palisadica was examined for secondary degeneration of axon terminals under the electron microscope. If the medial basal hypothalamus, including the suprachiasmatic area was disconnected from the rest of the brain, degenerated nerve endings do not occur in the palisade zone. Axon degeneration is observed if any part of the medio-basal area was separated from the median eminence or became necrotic. - These findings indicate that the nerve terminals in the zona palisadica arise exclusively from neurons in the medial basal hypothalamus, and that fibers of other origin do not terminate in this zone. The present observations support the assumption that the hypothalamic releasing (and inhibiting) factors are produced by, and the neural control of the anterior pituitary is exercised over a short final neuronal link, localized in the medial basal hypothalamus.

Original languageEnglish
Pages (from-to)145-158
Number of pages14
JournalExperimental Brain Research
Volume11
Issue number2
DOIs
Publication statusPublished - Sep 1970

Fingerprint

Middle Hypothalamus
Median Eminence
Nerve Endings
Herpes Zoster
Hypothalamus
Brain
Pituitary Hormone-Releasing Hormones
Presynaptic Terminals
Pituitary Gland
Axons
Electrons
Neurons

Keywords

  • Anterior pituitary control
  • Hypothalamic deafferentation
  • Hypothalamus
  • Median eminence

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Origin of the nerve endings in the surface zone of the median eminence of the rat hypothalamus. / Réthelyi, M.; Halász, B.

In: Experimental Brain Research, Vol. 11, No. 2, 09.1970, p. 145-158.

Research output: Contribution to journalArticle

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