Origin of serum catalase in acute liver congestion due to cardiac circulatory failure

Research output: Contribution to journalArticle

Abstract

In 28 patients with acute liver congestion due to cardiac circulatory failure increased values of serum catalase, liver enzymes (AST, ALT, LDH, and GLDH), and serum hemoglobin were followed up to six days. During five days of the effective therapy they fell to the reference range with similar kinetics. Catalase and hemoglobin release were estimated by a mathematical method. The fractional disappearance rate constants showed the faster elimination of serum hemoglobin than that of serum catalase. The total catalase release into the plasma was estimated to be 2353.2 ± 826.4 kU. The total hemoglobin release was found to be 0.171 ± 0.0429g. It meant 1.22 mL loss of blood which was responsible for 113 kU of released catalase being 4.8 per cent of total catalase release. The very high (237.8g i.e., 79.3%) g equivalent of myocardium indicated that the myocardium may not be the main source of the increased serum catalase. Other estimation showed that its contributions may not be more than 310.3 kU being 13.3 per cent of total catalase release. The reasonable loss (34.5g i.e. 2.3%) of liver cells, and the similar kinetics of serum catalase and liver enzymes suggested that main source (82.0-95.2%) of the increased serum catalase was the liver cell pool.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalClinical Chemistry and Enzymology Communications
Volume4
Issue number1
Publication statusPublished - Jun 27 1991

ASJC Scopus subject areas

  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Origin of serum catalase in acute liver congestion due to cardiac circulatory failure'. Together they form a unique fingerprint.

  • Cite this