In 28 patients with acute liver congestion due to cardiac circulatory failure increased values of serum catalase, liver enzymes (AST, ALT, LDH, and GLDH), and serum hemoglobin were followed up to six days. During five days of the effective therapy they fell to the reference range with similar kinetics. Catalase and hemoglobin release were estimated by a mathematical method. The fractional disappearance rate constants showed the faster elimination of serum hemoglobin than that of serum catalase. The total catalase release into the plasma was estimated to be 2353.2 ± 826.4 kU. The total hemoglobin release was found to be 0.171 ± 0.0429g. It meant 1.22 mL loss of blood which was responsible for 113 kU of released catalase being 4.8 per cent of total catalase release. The very high (237.8g i.e., 79.3%) g equivalent of myocardium indicated that the myocardium may not be the main source of the increased serum catalase. Other estimation showed that its contributions may not be more than 310.3 kU being 13.3 per cent of total catalase release. The reasonable loss (34.5g i.e. 2.3%) of liver cells, and the similar kinetics of serum catalase and liver enzymes suggested that main source (82.0-95.2%) of the increased serum catalase was the liver cell pool.
|Number of pages||6|
|Journal||Clinical Chemistry and Enzymology Communications|
|Publication status||Published - Jun 27 1991|
ASJC Scopus subject areas
- Clinical Biochemistry