Origin of follicular dendritic cell in the chicken spleen

Botond Zoltán Igyártó, A. Magyar, Imre Oláh

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The ellipsoid-associated cell (EAC) is a blood-borne phagocytic cell, residing in the antigen trapping zone of the chicken spleen. Binding and endocytosis of βGalactosidase (βGal) are independent from the Fc and complement receptors, because sulfated polysaccharides, in a concentration manner, inhibit the bacterial antigen uptake. The βGal-positive cells migrate to the periarterial lymphatic sheath (PALS), the preexisting germinal centers (GC), and form clusters with B- and T-cells. βGal, E5G12 double positive cells on the surface of the ellipsoid and in the PALS, GC and clusters prove that the EACs carry the enzyme. The EAC and the follicular dendritic cell (FDC) express, 68.2 and E5G12 and, 74.3 and E5G12, antigens, respectively. During migration the cessation of 68.2 and expression of 74.3 indicate the differentiation of EAC to FDC. By day 14 the clusters had disappeared, and in several GC the presence of double positive cells (74.3 and βGal; E5G12 and βGal) showed that the clusters had developed to GC. The presence of βGal+ cells in the PALS, where interdigitating dendritic cells (IDC) cooperate with the T-cells, suggests that in the spleen alternate routes exist for the EAC differentiation to FDC: EAC to FDC: βGal-loaded cells in the preexisting GC; and EAC through IDC to FDC: βGal+ EAC in the PALS and clusters. The EAC-FDC axis works exclusively inside the spleen; therefore; this system may be operated in pneumococcus infection.

Original languageEnglish
Pages (from-to)83-92
Number of pages10
JournalCell and Tissue Research
Volume327
Issue number1
DOIs
Publication statusPublished - Jan 2007

Fingerprint

Galactosidases
Follicular Dendritic Cells
Chickens
Spleen
Germinal Center
T-cells
Cells
Bacterial Antigens
Antigens
Complement Receptors
Dendritic Cells
Fc Receptors
Polysaccharides
T-Lymphocytes
Blood
Phagocytes
Endocytosis
Streptococcus pneumoniae

Keywords

  • Chicken
  • Ellipsoid-associated cells
  • Follicular dendritic cells
  • Spleen

ASJC Scopus subject areas

  • Anatomy
  • Clinical Biochemistry
  • Cell Biology

Cite this

Origin of follicular dendritic cell in the chicken spleen. / Igyártó, Botond Zoltán; Magyar, A.; Oláh, Imre.

In: Cell and Tissue Research, Vol. 327, No. 1, 01.2007, p. 83-92.

Research output: Contribution to journalArticle

Igyártó, Botond Zoltán ; Magyar, A. ; Oláh, Imre. / Origin of follicular dendritic cell in the chicken spleen. In: Cell and Tissue Research. 2007 ; Vol. 327, No. 1. pp. 83-92.
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