Origin and Distribution of Connective Tissue and Pericytes Impacting Vascularization in Brain Metastases With Different Growth Patterns

Vanda Téglási, Dániel T. Csűry, Katalin Dezső, Edina Bugyik, Vanessza Szabó, Zoltán Szállási, S. Paku, Lilla Reiniger

Research output: Contribution to journalArticle

Abstract

The impact of growth pattern on the distribution of connective tissue and on the vascularization of brain metastases (40 colon, lung and breast carcinoma samples) was analyzed. Most of the cases showed either a "pushing-type" (18/40, mostly colon and lung carcinomas) or a "papillary-type" (19/40, mostly breast carcinomas) growth pattern. There was a striking difference in the growth pattern and vascularization of colon/lung versus breast carcinoma metastases. Pushing-type brain metastases incorporated fewer vessels and accumulated more collagen in the adjacent brain parenchyma, whereas papillary-type brain metastases incorporated more vessels and accumulated collagen in the center of the tumor. We observed duplication of the PDGFRβ-positive pericyte layer accompanied by an increase in the amount of collagen within the vessel walls. The outer layer of pericytes and the collagen was removed from the vessel by invasive activity of the tumors, which occurred either peri- or intratumorally, depending on the growth pattern of the metastasis. Our findings suggest that pericytes are the main source of the connective tissue in brain metastases. Vascularization and connective tissue accumulation of the brain metastases largely depend on the growth pattern of the tumors.

Original languageEnglish
Pages (from-to)326-339
Number of pages14
JournalJournal of neuropathology and experimental neurology
Volume78
Issue number4
DOIs
Publication statusPublished - Apr 1 2019

Fingerprint

Pericytes
Connective Tissue
Neoplasm Metastasis
Brain
Growth
Collagen
Colon
Breast Neoplasms
Lung
Neoplasms
Carcinoma

Keywords

  • Brain metastasis
  • Connective tissue
  • Growth pattern
  • Pericytes
  • Vascularization

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Origin and Distribution of Connective Tissue and Pericytes Impacting Vascularization in Brain Metastases With Different Growth Patterns. / Téglási, Vanda; Csűry, Dániel T.; Dezső, Katalin; Bugyik, Edina; Szabó, Vanessza; Szállási, Zoltán; Paku, S.; Reiniger, Lilla.

In: Journal of neuropathology and experimental neurology, Vol. 78, No. 4, 01.04.2019, p. 326-339.

Research output: Contribution to journalArticle

Téglási, Vanda ; Csűry, Dániel T. ; Dezső, Katalin ; Bugyik, Edina ; Szabó, Vanessza ; Szállási, Zoltán ; Paku, S. ; Reiniger, Lilla. / Origin and Distribution of Connective Tissue and Pericytes Impacting Vascularization in Brain Metastases With Different Growth Patterns. In: Journal of neuropathology and experimental neurology. 2019 ; Vol. 78, No. 4. pp. 326-339.
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