Origin and distribution of connective tissue and pericytes impacting vascularization in brain metastases with different growth patterns

Vanda Teglasi, Daniel T. Csury, Katalin Dezso, Edina Bugyik, Vanessza Szabo, Zoltan Szallasi, Sandor Paku, Lilla Reiniger

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The impact of growth pattern on the distribution of connective tissue and on the vascularization of brain metastases (40 colon, lung and breast carcinoma samples) was analyzed. Most of the cases showed either a "pushing-type" (18/40, mostly colon and lung carcinomas) or a "papillary-type" (19/40, mostly breast carcinomas) growth pattern. There was a striking difference in the growth pattern and vascularization of colon/lung versus breast carcinoma metastases. Pushing-type brain metastases incorporated fewer vessels and accumulated more collagen in the adjacent brain parenchyma, whereas papillary-type brain metastases incorporated more vessels and accumulated collagen in the center of the tumor. We observed duplication of the PDGFRb-positive pericyte layer accompanied by an increase in the amount of collagen within the vessel walls. The outer layer of pericytes and the collagen was removed from the vessel by invasive activity of the tumors, which occurred either peri-or intratumorally, depending on the growth pattern of the metastasis. Our findings suggest that pericytes are the main source of the connective tissue in brain metastases. Vascularization and connective tissue accumulation of the brain metastases largely depend on the growth pattern of the tumors.

Original languageEnglish
Pages (from-to)326-339
Number of pages14
JournalJournal of Neuropathology and Experimental Neurology
Volume78
Issue number4
DOIs
Publication statusPublished - Jan 1 2019

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Keywords

  • Brain metastasis
  • Connective tissue
  • Growth pattern
  • Pericytes
  • Vascularization

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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