Organizer and regulatory role of colonic isolated lymphoid follicles in inflammation

M. Constantinovits, F. Sípos, B. Molnár, Z. Tulassay, G. Müzes

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Gut-associated lymphoid tissue (GALT) is supposed to play an integral role in the organization of colonic repair mechanisms. Majority of the GALT is composed of isolated and aggregated lymphoid follicles distributed throughout the intestines. These lymphoid follicles, including Peyer's patches of the small, and isolated lymphoid follicles (ILFs) of both the small and large intestines, are composed of a specialised follicle associated epithelium overlying a subepithelial dome containing numerous dendritic cells, macrophages, T and B cells. Within inflammatory conditions the number, the diameter and the density of ILFs are increasing. Follicles are involved not just in immune surveillance, but their presence is also indispensable for normal colonic mucosal regeneration. Regarding mucosal repair the relation of ILFs to bone marrow derived stem cells, follicular dendritic cells, subepithelial myofibroblasts and crypt formations, and the putative organizer role of ILFs have not been clarified yet.

Original languageEnglish
Pages (from-to)344-352
Number of pages9
JournalActa Physiologica Hungarica
Volume99
Issue number3
DOIs
Publication statusPublished - Sep 1 2012

Fingerprint

Lymphoid Tissue
Follicular Dendritic Cells
Inflammation
Peyer's Patches
Myofibroblasts
Large Intestine
Dendritic Cells
Small Intestine
Intestines
Regeneration
B-Lymphocytes
Stem Cells
Epithelium
Bone Marrow
Macrophages
T-Lymphocytes

Keywords

  • bone marrow derived stem cells
  • colonic inflammation
  • epithelial repair
  • follicular dendritic cell
  • isolated lymphoid follicle
  • myofibroblast

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

Organizer and regulatory role of colonic isolated lymphoid follicles in inflammation. / Constantinovits, M.; Sípos, F.; Molnár, B.; Tulassay, Z.; Müzes, G.

In: Acta Physiologica Hungarica, Vol. 99, No. 3, 01.09.2012, p. 344-352.

Research output: Contribution to journalArticle

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