Organizational aspects of the citric acid cycle.

P. Srere, B. Sümegi, A. D. Sherry

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The enzymes of the citric acid cycle show at least two levels of organization within the mitochondrial matrix. Six of the possible eight sequential enzymes show specific interactions in vitro. Further, the enzymes bind specifically to the matrix surface of the inner membrane. A slightly damaged mitochondrial particle has been isolated which contains bound, but exposed, Krebs citric acid cycle enzymes. This particle (a metabolon) shows a kinetic advantage for two coupled systems, fumarate oxidation and malate conversion to citrate, over a solubilized system. N.m.r. experiments indicate that many components of the matrix are in a bound state.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalBiochemical Society Symposia
Volume54
Publication statusPublished - 1987

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Citric Acid Cycle
Enzymes
Fumarates
Citric Acid
Membranes
Oxidation
Kinetics
Experiments

ASJC Scopus subject areas

  • Biochemistry

Cite this

Organizational aspects of the citric acid cycle. / Srere, P.; Sümegi, B.; Sherry, A. D.

In: Biochemical Society Symposia, Vol. 54, 1987, p. 173-178.

Research output: Contribution to journalArticle

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