Szájüregi laphámrákok az eszakkelet-magyarországi régióban. II. Etiológiai faktorok.

Translated title of the contribution: Oral squamous cell carcinoma in north-eastern Hungary. II. Etiological factors

Judit Nemes, Róbert Boda, Pál Redl, I. Márton

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this study is to determine the possible etiological factors of oral squamous cell carcinoma (OSCC) in North-Eastern Hungary. The medical records of 119 randomly selected patients with OSCC admitted to the Department of Maxillofacial Surgery of the Faculty of Dentistry, University of Debrecen were reviewed. The following risk factors were investigated: tobacco and alcohol consumption, dental status, rural vs. urban residence, and high risk HPV infection. The presence of HPV DNA has been evaluated by polymerase chain reaction from the tissue samples. Results were correlated with clinical data. At the time of diagnosis 65.5 percent of the patients were smokers. Under the age of 45 the rate was 86.4%. Smoking significantly correlated with younger age, male gender, advanced clinical stages and alcohol consumption. The majority of the patients (75.5%) consumed alcohol, 41.1% regularly over the acceptable range. Drinking habit significantly correlated with younger age, male gender and tumor site (gingiva, retromolar region, tongue). HR-HPV types were detected in 42.8% of samples tested. HPV DNA presence was not related to gender, clinical stage, histological grade or other risk factors. Authors found weak correlation between HR-HPV positivity, younger patient age and better 5-year survival rate. The dental status was acceptable only in 12.6 percent of the cases. There was a correlation between dental status and age, smoking and drinking habits. No significant urban-rural differences were found. In the study population the most important risk factor for developing oral cancer is tobacco smoking followed by alcohol consumption. Avoidance of tobacco smoking and a reduced amount of alcohol, together with healthy nutrition and regular dental care should be emphasized.

Original languageHungarian
Pages (from-to)179-185
Number of pages7
JournalFogorvosi szemle
Volume99
Issue number5
Publication statusPublished - Oct 2006

Fingerprint

Hungary
Squamous Cell Carcinoma
Smoking
Alcohol Drinking
Tooth
Drinking
Habits
Alcohols
Dental Care
Oral Surgery
Mouth Neoplasms
DNA
Tobacco Use
Gingiva
Dentistry
Tongue
Medical Records
Survival Rate
Polymerase Chain Reaction
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szájüregi laphámrákok az eszakkelet-magyarországi régióban. II. Etiológiai faktorok. / Nemes, Judit; Boda, Róbert; Redl, Pál; Márton, I.

In: Fogorvosi szemle, Vol. 99, No. 5, 10.2006, p. 179-185.

Research output: Contribution to journalArticle

Nemes, Judit ; Boda, Róbert ; Redl, Pál ; Márton, I. / Szájüregi laphámrákok az eszakkelet-magyarországi régióban. II. Etiológiai faktorok. In: Fogorvosi szemle. 2006 ; Vol. 99, No. 5. pp. 179-185.
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