Oral phenoxymethylpenicillin treatment during pregnancy. Results of a population-based Hungarian case-control study

E. Czeizel, M. Rockenbauer, Jørn Olsen, Henrik T. Sørensen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The objective of the study was to examine the human teratogenic potential of oral penicillin V: phenoxymethylpenicillin treatment during pregnancy in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. The dataset included 22,865 pregnant women who had fetuses or newborns with congenital abnormalities and 38,151 matched pregnant women who had newborn infants without any congenital abnormality (population control group). Of 22,865 case pregnant women, 173 (0.8%) had phenoxymethylpenicillin treatments, while of 38,151 population controls, 218 (0.6) were treated by this penicillin V (crude OR 1.3 with 95% CI: 1.1-1.6). This difference was explained mainly by recall bias and confounders because adjusted OR for medically documented phenoxymethylpenicillin treatments did not show difference during the second-third months of gestation, i.e. in the critical period for most major congenital abnormalities in case-matched control pairs. Thus, treatment with oral phenoxymethylpenicillin during pregnancy presents very little if any teratogenic risk to the fetus.

Original languageEnglish
Pages (from-to)178-181
Number of pages4
JournalArchives of Gynecology and Obstetrics
Volume263
Issue number4
Publication statusPublished - Apr 2000

Fingerprint

Penicillin V
Case-Control Studies
Pregnancy
Population
Pregnant Women
Population Control
Fetus
Therapeutics
Newborn Infant
Population Groups
Control Groups

Keywords

  • Case-control analysis
  • Congenital abnormalities
  • Penicillin V: phenoxymethylpenicillin
  • Penicillins
  • Teratogen potential

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Oral phenoxymethylpenicillin treatment during pregnancy. Results of a population-based Hungarian case-control study. / Czeizel, E.; Rockenbauer, M.; Olsen, Jørn; Sørensen, Henrik T.

In: Archives of Gynecology and Obstetrics, Vol. 263, No. 4, 04.2000, p. 178-181.

Research output: Contribution to journalArticle

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