Oral immunization with an rfaH mutant elicits protection against salmonellosis in mice

Gábor Nagy, Ulrich Dobrindt, Jörg Hacker, Levente Emödy

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Loss of the transcriptional antiterminator RfaH results in virulence attenuation (>104-fold increase in 50% lethal dose) of the archetypal Salmonella enterica serovar Typhimurium strain SL1344 by both orogastric and intraperitoneal routes of infection in BALB/c mice. Oral immunization with the mutant efficiently protects mice against a subsequent oral infection with the wild-type strain. Interestingly, in vitro immunoreactivity is not confined to strain SL1344; rather, it is directed also towards other serovars of S. enterica and even Salmonella bongori strains.

Original languageEnglish
Pages (from-to)4297-4301
Number of pages5
JournalInfection and Immunity
Volume72
Issue number7
DOIs
Publication statusPublished - Jul 1 2004

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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