Oral clefts with associated anomalies: Methodological issues

Diego F. Wyszynski, Andrea Sárközi, Andrew E. Czeizel

Research output: Contribution to journalReview article

46 Citations (Scopus)


Objective: To discuss methodological factors that account for the wide variation in the reported prevalence rates of anomalies associated with oral clefts. Conclusions: The published prevalences of associated anomalies vary considerably because of the following: (1) differences in case definition and inclusion/exclusion criteria; (2) length of time after birth that cases are examined; (3) variability of clinical expression of associated anomalies; (4) knowledge and technology available to produce syndrome delineation; (5) selection of patients, sources of ascertainment, and sample size; and (6) true population differences and changes in frequency over time.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalCleft Palate-Craniofacial Journal
Issue number1
Publication statusPublished - Jan 1 2006



  • Birth defects
  • Cleft lip and palate
  • Congenital anomalies
  • Craniofacial malformations
  • Syndrome

ASJC Scopus subject areas

  • Oral Surgery
  • Otorhinolaryngology

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