A 2-es típusú diabetes orális kezelése

Translated title of the contribution: Oral antidiabetic treatment of type 2 diabetes mellitus

Somogyi Anikó, Nagy Géza, Varga Tímea, Rosta Klára

Research output: Contribution to journalArticle

Abstract

Evidence based medical guidelines for the treatment of type 2 diabetes mellitus focus on three areas: lifestyle changes, radical treatment of cardiovascular risk factors and normalization of blood glucose levels. Type 2 diabetes mellitus can be characterized by peripheral insulin resistance, diminished secretion of insulin of the pancreas, and increased glucose production of the liver. The therapeutic agents used to treat T2DM beneficially influence one or more of these abnormalities. Metformin belongs to the first-line treatment of T2DM, which ameliorates peripheral insulin resistance and diminishes glucose production of the liver. Further therapeutic choices are sulfonylureas, which enhance insulin secretion, alpha-glycosidase inhibitors, and thiazolidinediones. In the clinical practice of the last few years incretin mimetic compounds and DPP4 inhibitors, which enhance incretin effect, have also been administered. In order to normalize blood glucose level, drugs with different mechanism of action can be coadministered and most of them can be supplemented with insulin treatment.

Original languageHungarian
Pages (from-to)145-154
Number of pages10
JournalOrvoskepzes
Volume85
Issue number2
Publication statusPublished - Dec 1 2010

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anikó, S., Géza, N., Tímea, V., & Klára, R. (2010). A 2-es típusú diabetes orális kezelése. Orvoskepzes, 85(2), 145-154.