Oral anticoagulant therapy and bleeding events with Vitamin K antagonists in patients with Atrial fibrillation in a Hungarian County hospital

Laszlo Mark, Győző Dani, Robert Vendrey, György Paragh, Andras Katona

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Vitamin K antagonists, despite their tight therapeutic spectrum and the fear of bleeding complications, were long the most important drugs used in anticoagulant therapy. The aim of this study was to evaluate the quality of anticoagulant therapy and its relation with bleedings in everyday clinical practice.

Material/Methods: We analyzed the data of 272 patients with non-valvular atrial fibrillation treated in our county hospital using retrospective data collection of the last 1008±384 days. The INR (International Normalized Ratio) values and the time in therapeutic range (TTR) were analyzed. We asked patients about bleeding complications and searched the medical records.

Results: The TTR proved to be 64% and there was no statistically significant difference between that of 252 (92.7%) patients taking acenocoumarol and 20 (7.3%) on warfarin. Analyzing various factors leading to TTR under 70%, we found that none of them have a significant impact. Significantly more bleeding events occurred in the first 3 months after the initiation of anticoagulant therapy and in patients with TTR under 70%, but the latter was not significant after adjustment for factors influencing bleeding (OR 1.607, CI 0.571–4.522, p=0.392).

Conclusions: Although the present study’s TTR values were similar to those found in the warfarin branch of various largescale international trials and in real-life settings, further improvement of vitamin K antagonist therapy are necessary. As the possibilities for this are limited, we believe that the new type anticoagulant agents have a place in everyday clinical practice.

Original languageEnglish
Pages (from-to)518-525
Number of pages8
JournalMedical Science Monitor
Volume21
DOIs
Publication statusPublished - Feb 17 2015

Keywords

  • Anticoagulants
  • Atrial Fibrillation
  • Warfarin

ASJC Scopus subject areas

  • Medicine(all)

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