Optimizing the Crystal Habit of Glycine by Using an Additive for Impinging Jet Crystallization

Tímea Tari, Rita Ambrus, Gerda Szakonyi, Dániel Madarász, Patrick Frohberg, Ildikó Csóka, P. Szabó-Révész, Joachim Ulrich, Z. Aigner

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Additives selectively inhibit or enhance the growth of crystal faces and effectively change the crystal morphology. For the first time, potassium chloride was used as additive during impinging jet crystallization of glycine. The structure of the powder particles was evaluated by X-ray powder diffraction, differential scanning calorimetry, scanning electron microscopy with energy dispersive X-ray spectroscopy, headspace gas chromatography, and flame atomic absorption spectrometry. Even a minor amount of KCl had a significant effect on the crystal roundness and reduced the particle size significantly, despite of the extremely rapid nature of the crystallization process. This method resulted in the α-polymorph of glycine with an appropriate low residual additive content and a minimal residual organic solvent content. The arrangement and the optimal concentration of the additive were determined.

Original languageEnglish
Pages (from-to)1323-1331
Number of pages9
JournalChemical Engineering and Technology
Volume40
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

Keywords

  • Additives
  • Glycine
  • Impinging jet crystallization
  • Particle size
  • Polymorphism

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

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