Optimizing experimental conditions for minimum production cost in preparative chromatography

Attila Felinger, Georges Guiochon

Research output: Contribution to journalArticle

53 Citations (Scopus)


Optimum experimental conditions and column design parameters are calculated for most economical separation of binary mixtures by preparative liquid chromatography. The solvent consumption and capital costs are regarded as the two major cost contributions. Calculations were performed by using the numerical solution of the equilibrium‐dispersive model of chromatography and a nonlinear simplex algorithm. Solvent consumption depends only on the column efficiency, the retention factor, and the loading factor. The production rate depends on the particle size, the column length, the mobile‐phase flow velocity, the retention and the loading factors, and can be optimized with or without recovery yield constraints. A hybrid objective function was constructed to find the tradeoffs between the production rate and the solvent consumption.

Original languageEnglish
Pages (from-to)594-605
Number of pages12
JournalAIChE Journal
Issue number4
Publication statusPublished - Apr 1994

ASJC Scopus subject areas

  • Biotechnology
  • Environmental Engineering
  • Chemical Engineering(all)

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