Optimized simulation and validation of particle advection in asymmetric staggered herringbone type micromixers

Eszter L. Tóth, Eszter G. Holczer, Kristóf Iván, Péter Fürjes

Research output: Contribution to journalArticle

15 Citations (Scopus)


This paper presents and compares two different strategies in the numerical simulation of passive microfluidic mixers based on chaotic advection. In addition to flow velocity field calculations, concentration distributions of molecules and trajectories of microscale particles were determined and compared to evaluate the performance of the applied modeling approaches in the proposed geometries. A staggered herringbone type micromixer (SHM) was selected and studied in order to demonstrate finite element modeling issues. The selected microstructures were fabricated by a soft lithography technique, utilizing multilayer SU-8 epoxy-based photoresist as a molding replica for polydimethylsiloxane (PDMS) casting. The mixing processes in the microfluidic systems were characterized by applying molecular and particle (cell) solutions and adequate microscopic visualization techniques. We proved that modeling of the molecular concentration field is more costly, in regards to computational time, than the particle trajectory based method. However, both approaches showed adequate qualitative agreement with the experimental results.

Original languageEnglish
Pages (from-to)136-150
Number of pages15
Issue number1
Publication statusPublished - Jan 1 2015


  • Concentration distribution
  • Experimental validation
  • Finite element modeling
  • Particle trajectory
  • Staggered herringbone micromixer (SHM)

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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