Optimization of the Synthesis of Flavone-Amino Acid and Flavone-Dipeptide Hybrids via Buchwald-Hartwig Reaction

Dávid Pajtás, Krisztina Kónya, Attila Kiss-Szikszai, Petr Džubák, Zoltán Pethő, Z. Varga, G. Panyi, T. Patonay

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The article describes the development of Buchwald-Hartwig amination of different bromoflavones with amino acid and peptide derivatives as nitrogen source giving unique structures. The previously observed racemization, which occurred during the synthesis of flavone-amino acid hybrids, was successfully prevented in most cases. The biological assays of these novel structures showed cytotoxic effects on different cancer cell lines.

Original languageEnglish
Pages (from-to)4578-4587
Number of pages10
JournalJournal of Organic Chemistry
Volume82
Issue number9
DOIs
Publication statusPublished - May 5 2017

ASJC Scopus subject areas

  • Organic Chemistry

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