Optimization of the reduction of 74 As(V) to 74 As(III) and of the labelling of dithiol dihydrolipoic acid

Zita Oláh, Andreas T.J. Vogg, Tibor Kremmer, Zoltán Szűcs, Z. Varga, Rita Dóczi

Research output: Contribution to journalArticle

Abstract

The radiochemical separation of n.c.a. arsenic on its own or for radio-labelling purposes usually involves the issue of reducing arsenic(V). Numerous approaches for reducing pentavalent arsenic have been examined. A novel HPLC method has also been presented for accessing the efficiency of the reduction in terms of *As(III)/*As(V). Labelling with trivalent radioarsenic seems to be a promising research field to access new radiopharmaceuticals, for example, using arsenic as a surrogate for phosphorus. Moreover, as a model system, the labelling reaction of *As(III) with dihydrolipoic acid has been systematically optimized.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalApplied Radiation and Isotopes
Volume149
DOIs
Publication statusPublished - Jul 1 2019

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ASJC Scopus subject areas

  • Radiation

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