Optimization of the production process and product quality of titanate nanotube–drug composites

Yasmin Ranjous, Géza Regdon, Klára Pintye-Hódi, Tamás Varga, Imre Szenti, Zoltán Kónya, Tamás Sovány

Research output: Contribution to journalArticle

Abstract

Recently, there has been an increasing interest in the application of nanotubular structures for drug delivery. There are several promising results with carbon nanotubes; however, in light of some toxicity issues, the search for alternative materials has come into focus. The objective of the present study was to investigate the influence of the applied solvent on the composite formation of titanate nanotubes (TNTs) with various drugs in order to improve their pharmacokinetics, such as solubility, stability, and bioavailability. Composites were formed by the dissolution of atenolol (ATN) and hydrochlorothiazide (HCT) in ethanol, methanol, 0.01 M hydrochloric acid or in ethanol, 1M sodium hydroxide, dimethylformamide (DMF), dimethyl sulfoxide (DMSO), respectively, and then they were mixed with a suspension of TNTs under sonication for 30 min and vacuum-dried for 24 h. The structural properties of composites were characterized by SEM, TEM, FT-IR, differential scanning calorimetry (DSC), thermogravimetric (TG) analysis, and optical contact angle (OCA) measurements. Drug release was determined from the fast disintegrating tablets using a dissolution tester coupled with a UV–Vis spectrometer. The results revealed that not only the good solubility of the drug in the applied solvent, but also the high volatility of the solvent, is necessary for an optimal composite-formation process.

Original languageEnglish
Article number1406
JournalNanomaterials
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 2019

    Fingerprint

Keywords

  • Atenolol
  • Composite formation
  • Hydrochlorothiazide
  • Solvent selection
  • Titanate nanotubes

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)

Cite this