Optimization of preparation of matrix pellets containing Eudragit ® NE 30D

E. Bölcskei, G. Regdon, T. Sovány, P. Kleinebudde, K. Pintye-Hódi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Matrix pellets containing Eudragit NE 30D were produced by extrusion-spheronization, where the critical control points of the process were detected by means of a factorial design. The factors were the quantity of water, the dosing speed, the spheronization speed and the duration of spheronization. The breaking hardness and aspect ratio were measured and the significant factors were determined. On the basis of the results, a new combination of factors was used, which resulted in matrix pellets with the best characteristics.

Original languageEnglish
Pages (from-to)651-657
Number of pages7
JournalChemical Engineering Research and Design
Volume90
Issue number5
DOIs
Publication statusPublished - May 1 2012

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Keywords

  • Extrusion
  • Formulation
  • Morphology
  • Pharmaceuticals
  • Polymers
  • Spheronization

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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