Optimization of preparation of matrix pellets containing ethylcellulose

Elnazeer I. Hamedelniel, János Bajdik, K. Pintye-Hódi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The aim of this study was to investigate the effects of the parameters of the spheronization and the nature of the wetting liquid on the properties of matrix pellets prepared by extrusion and spheronization. Ethylcellulose was used as a matrix former, microcrystalline cellulose as a filler, atenolol as a model active agent, and water and a water-ethanol mixture as liquids. The formation of the pellets and the interactions of the components were evaluated via mechanical, dissolution and morphological studies on the pellets. A factorial design was used to determine the effects of the evaluated factors. It was concluded that significant effects were exerted not only by the operational parameters, but also by the nature of the liquid. The breaking hardness and the dissolution revealed that the ethanol in the liquid caused changes in the wettability of the components and consequently in the matrix structure. This was explained by a comparison of the relative importance of the factors. The alterations induced by ethanol were preferable in the dissolution, because the possibility of the burst effect in the first phase of dissolution can then be avoided. However, it is not favourable as concerns the sphericity and the mechanical properties of the pellets.

Original languageEnglish
Pages (from-to)120-124
Number of pages5
JournalChemical Engineering and Processing: Process Intensification
Volume49
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

Dissolution
Ethanol
Liquids
Wetting
Atenolol
Water
Extrusion
Fillers
Cellulose
Hardness
Mechanical properties
ethyl cellulose

Keywords

  • Breaking hardness
  • Dissolution
  • Ethylcellulose
  • Extrusion/spheronization
  • Factorial design
  • Wetting

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)
  • Industrial and Manufacturing Engineering
  • Energy Engineering and Power Technology

Cite this

Optimization of preparation of matrix pellets containing ethylcellulose. / Hamedelniel, Elnazeer I.; Bajdik, János; Pintye-Hódi, K.

In: Chemical Engineering and Processing: Process Intensification, Vol. 49, No. 1, 2010, p. 120-124.

Research output: Contribution to journalArticle

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