Optimization of an optrode microdevice for infrared neural stimulation

C. Boros, C. Horváth, S. Beleznai, Sepsi, D. Csosz, Z. Fekete, P. Koppa

Research output: Contribution to journalArticle

Abstract

Infrared light is a promising candidate for the treatment of neurodegenerative diseases. Optimizing the device parameters to achieve the best optical and mechanical performance is essential for reliable in vivo operation. In this work, mechanical strength simulations and coupled optical and thermal model were used to determine optimal design parameters for maximizing overall device efficiency. Our analysis reveals that minimizing the number of integrated optical elements and optimizing the optical path leads to a 33% relative in-coupling efficiency improvement at equal mechanical robustness. Using a symmetric optrode tip with an angle of 15°, the efficiency showed a further 17% relative improvement due to the enhancement of out-coupling at the tip. To investigate the temperature rise of the brain tissue during the infrared stimulation in the case of the optimized device, a thermal simulation with pulsed infrared excitation was developed. Our results show that the optimized device provides a temperature rise of 4.42°C as opposed to 3°C for the original setup.

Original languageEnglish
Pages (from-to)3870-3876
Number of pages7
JournalApplied Optics
Volume58
Issue number14
DOIs
Publication statusPublished - Jan 1 2019

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stimulation
Infrared radiation
optimization
Neurodegenerative diseases
Optical devices
thermal simulation
Strength of materials
Brain
optical paths
Tissue
brain
Temperature
temperature
augmentation
excitation
Hot Temperature
simulation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

Cite this

Boros, C., Horváth, C., Beleznai, S., Sepsi, Csosz, D., Fekete, Z., & Koppa, P. (2019). Optimization of an optrode microdevice for infrared neural stimulation. Applied Optics, 58(14), 3870-3876. https://doi.org/10.1364/AO.58.003870

Optimization of an optrode microdevice for infrared neural stimulation. / Boros, C.; Horváth, C.; Beleznai, S.; Sepsi; Csosz, D.; Fekete, Z.; Koppa, P.

In: Applied Optics, Vol. 58, No. 14, 01.01.2019, p. 3870-3876.

Research output: Contribution to journalArticle

Boros, C, Horváth, C, Beleznai, S, Sepsi, Csosz, D, Fekete, Z & Koppa, P 2019, 'Optimization of an optrode microdevice for infrared neural stimulation', Applied Optics, vol. 58, no. 14, pp. 3870-3876. https://doi.org/10.1364/AO.58.003870
Boros C, Horváth C, Beleznai S, Sepsi, Csosz D, Fekete Z et al. Optimization of an optrode microdevice for infrared neural stimulation. Applied Optics. 2019 Jan 1;58(14):3870-3876. https://doi.org/10.1364/AO.58.003870
Boros, C. ; Horváth, C. ; Beleznai, S. ; Sepsi ; Csosz, D. ; Fekete, Z. ; Koppa, P. / Optimization of an optrode microdevice for infrared neural stimulation. In: Applied Optics. 2019 ; Vol. 58, No. 14. pp. 3870-3876.
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