Optical resolution of racemic alcohols via diastereoisomeric supramolecular compound formation with O,O'-dibenzoyl-(2R,3R)-tartaric acid

Csaba Kassai, Zoltán Juvancz, József Bálint, Elemér Fogassy, Dávid Kozma

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

O,O'-Dibenzoyl-(2R,3R)-tartaric acid (DBTA) forms a hydrogen bonded supramolecular compound with alcohols. The supra-molecular compound formation is enantioselective for a large number of chiral alcohols, therefore DBTA can be used as resolving agent, also for compounds having no basic group. The condition of the complex formation is that the guest molecule should contain a proton donating group and a fitting aliphatic chain or cycloalkane ring. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)8355-8359
Number of pages5
JournalTetrahedron
Volume56
Issue number42
DOIs
Publication statusPublished - Oct 13 2000

    Fingerprint

Keywords

  • (2R,3R)-tartaric acid
  • O,O'-dibenzoyl-(2R,3R)-tartaric acid
  • Racemic compounds

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this