Optical resolution of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline by supercritical fluid extraction

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7 Citations (Scopus)

Abstract

6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) enantiomers were separated by supercritical fluid extraction using carbon dioxide. Diastereoisomeric salts were formed from the racemic base with less than one equivalent of O,O′-di-(4-toluoyl)-(2R,3R)-tartaric acid (DPTTA). Further purification was achieved by partial salt formation of the enantiomeric mixture with an achiral acid (HCl) followed by the supercritical fluid extraction of the free enantiomers.

Original languageEnglish
Pages (from-to)568-570
Number of pages3
JournalChirality
Volume13
Issue number9
DOIs
Publication statusPublished - Oct 20 2001

Keywords

  • 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline
  • Carbon dioxide
  • Chiral resolution
  • Diastereoisomeric salt formation
  • Enantiomer
  • Optical resolution
  • Supercritical fluid extraction (SFE)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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