Optical resolution methods

E. Fogassy, Mihály Nógrádi, Dávid Kozma, G. Egri, Emese Pálovics, Violetta Kiss

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Despite the large number of elaborate enantioselective syntheses for the preparation of a single enantiomer to achieve industrial and scientific goals, the separation and purification of enantiomers (components of racemic compounds) is also necessary. Hence, we present the most often used thought-provoking modern methods based on momentous recognitions (e.g. spontaneous resolution, induced crystallization, resolution by formation of diastereomers, resolution by formation of non-covalent diastereomers, resolution by diastereomeric salt formation, resolution by diastereomeric complex formation, "half equivalent" methods of resolution, separation by crystallization, separation by distillation, separation by supercritical fluid extraction, resolution with mixtures of resolving agents, resolution with a derivative of the target compound, enantioselective chromatography, resolution by formation of covalent diastereomers, resolution by substrate selective reaction, kinetic resolution without enzymes, kinetic resolution by enzyme catalysis, hydrolytic and redox enzymes, kinetic and thermodynamic control, resolutions combined with 2nd order asymmetric transformations, enrichment of partially resolved mixtures, role of the solvent and methods of optimization in the separation of diastereoisomers, non-linear effects and selected examples of resolution on an industrial scale).

Original languageEnglish
Pages (from-to)3011-3030
Number of pages20
JournalOrganic and Biomolecular Chemistry
Volume4
Issue number16
DOIs
Publication statusPublished - 2006

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Enzyme kinetics
Crystallization
Enzymes
Enantiomers
Supercritical Fluid Chromatography
Distillation
Catalysis
Thermodynamics
Oxidation-Reduction
Chromatography
Salts
Supercritical fluids
enzymes
Purification
enantiomers
Derivatives
Substrates
crystallization
distillation
supercritical fluids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)

Cite this

Fogassy, E., Nógrádi, M., Kozma, D., Egri, G., Pálovics, E., & Kiss, V. (2006). Optical resolution methods. Organic and Biomolecular Chemistry, 4(16), 3011-3030. https://doi.org/10.1039/b603058k

Optical resolution methods. / Fogassy, E.; Nógrádi, Mihály; Kozma, Dávid; Egri, G.; Pálovics, Emese; Kiss, Violetta.

In: Organic and Biomolecular Chemistry, Vol. 4, No. 16, 2006, p. 3011-3030.

Research output: Contribution to journalArticle

Fogassy, E, Nógrádi, M, Kozma, D, Egri, G, Pálovics, E & Kiss, V 2006, 'Optical resolution methods', Organic and Biomolecular Chemistry, vol. 4, no. 16, pp. 3011-3030. https://doi.org/10.1039/b603058k
Fogassy, E. ; Nógrádi, Mihály ; Kozma, Dávid ; Egri, G. ; Pálovics, Emese ; Kiss, Violetta. / Optical resolution methods. In: Organic and Biomolecular Chemistry. 2006 ; Vol. 4, No. 16. pp. 3011-3030.
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