Optical resolution in two immiscible solvents in the presence of an intermediate solvent. Optical resolution of N-methyl-amphetamine by O,O'- dibenzoyl-R,R-tartaric acid in dichloroethane-water-methanol solvent system

Dávid Kozma, Elemér Fogassy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A new optical resolution method was developed by the use of a two phase three component solvent system and demonstrated on the example of the resolution of the N-methyl-amphetamine with O,O'-dibenzoyl-R,R-tartaric acid. By adding methanol as an intermediate solvent to the two phase water- dichlorocthane solvent system the solubility and the optical purity of the precipitated salt can be adjusted in wide ranges. By this way a highly efficient one step resolution process can be accomplished.

Original languageEnglish
Pages (from-to)4315-4319
Number of pages5
JournalSynthetic Communications
Volume29
Issue number24
DOIs
Publication statusPublished - Jan 1 1999

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ASJC Scopus subject areas

  • Organic Chemistry

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