A new optical resolution method was developed by the use of a two phase three component solvent system and demonstrated on the example of the resolution of the N-methyl-amphetamine with O,O'-dibenzoyl-R,R-tartaric acid. By adding methanol as an intermediate solvent to the two phase water- dichlorocthane solvent system the solubility and the optical purity of the precipitated salt can be adjusted in wide ranges. By this way a highly efficient one step resolution process can be accomplished.
ASJC Scopus subject areas
- Organic Chemistry