Optical resolution in two immiscible solvents in the presence of an intermediate solvent. Optical resolution of N-methyl-amphetamine by O,O'- dibenzoyl-R,R-tartaric acid in dichloroethane-water-methanol solvent system

Dávid Kozma, E. Fogassy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A new optical resolution method was developed by the use of a two phase three component solvent system and demonstrated on the example of the resolution of the N-methyl-amphetamine with O,O'-dibenzoyl-R,R-tartaric acid. By adding methanol as an intermediate solvent to the two phase water- dichlorocthane solvent system the solubility and the optical purity of the precipitated salt can be adjusted in wide ranges. By this way a highly efficient one step resolution process can be accomplished.

Original languageEnglish
Pages (from-to)4315-4319
Number of pages5
JournalSynthetic Communications
Volume29
Issue number24
Publication statusPublished - 1999

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Ethylene Dichlorides
Amphetamine
Methanol
Water
Solubility
Salts
tartaric acid

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

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abstract = "A new optical resolution method was developed by the use of a two phase three component solvent system and demonstrated on the example of the resolution of the N-methyl-amphetamine with O,O'-dibenzoyl-R,R-tartaric acid. By adding methanol as an intermediate solvent to the two phase water- dichlorocthane solvent system the solubility and the optical purity of the precipitated salt can be adjusted in wide ranges. By this way a highly efficient one step resolution process can be accomplished.",
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AU - Fogassy, E.

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N2 - A new optical resolution method was developed by the use of a two phase three component solvent system and demonstrated on the example of the resolution of the N-methyl-amphetamine with O,O'-dibenzoyl-R,R-tartaric acid. By adding methanol as an intermediate solvent to the two phase water- dichlorocthane solvent system the solubility and the optical purity of the precipitated salt can be adjusted in wide ranges. By this way a highly efficient one step resolution process can be accomplished.

AB - A new optical resolution method was developed by the use of a two phase three component solvent system and demonstrated on the example of the resolution of the N-methyl-amphetamine with O,O'-dibenzoyl-R,R-tartaric acid. By adding methanol as an intermediate solvent to the two phase water- dichlorocthane solvent system the solubility and the optical purity of the precipitated salt can be adjusted in wide ranges. By this way a highly efficient one step resolution process can be accomplished.

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