Optical resolution by crystallization from melt using enantiomer derivatives as resolving agents: Nonlinear behavior of resolving agent mixtures

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6 Citations (Scopus)

Abstract

Substituted racemic 1-phenylethylamine derivatives were reacted in molten phase with chiral N-substituted 1-phenylethylamine dicarboxylic acid derivatives (4-9), and their mixtures (e.g., 4+6, 7+8, etc.) in different ratios, and the crystalline quasi-racemic diastereomers so formed were separated. Nonlinear behavior of the mixtures of resolving agents having related structure and considerable positive and negative chiral-chiral interactions were observed.

Original languageEnglish
Pages (from-to)565-569
Number of pages5
JournalChirality
Volume17
Issue number9
DOIs
Publication statusPublished - Nov 7 2005

Keywords

  • Enantiomer
  • Melt
  • Nonlinear
  • Related structure
  • Resolution

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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