Opsonic activity of cord blood sera against various species of microorganism

L. Máródi, Peter C J Leijh, Armando Braat, Mohamed R. Daha, Ralph Van Furth

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The results of the present study on the opsonic activity of cord blood serum against various micro­organisms (Staphylococcus aureus, Escherichia coli, and group B streptococci) show that the activity of cord blood serum in promoting IgG-mediated ingestion is equal to that of sera of healthy adults. This implies that IgG concentra­tions, as assessed by immunochemical methods, in cord blood and adult sera represent functionally similar IgG activities. Ingestion of microorganisms involving comple­ment-dependent opsonization was found to be of the same level for cord blood and adult sera, when the opsonization occurred via the classical pathway of complement activa­tion. However, due to decreased concentrations of factors B, P, and D in cord blood serum, optimal opsonization of microorganisms requiring the alternative pathway of com­plement was impaired. Taken together, these results indi­cate that an opsonic defect of cord blood serum affects mainly microorganisms requiring opsonization via the al­ternative pathway of complement.

Original languageEnglish
Pages (from-to)433-436
Number of pages4
JournalPediatric Research
Volume19
Issue number5
Publication statusPublished - 1985

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Fetal Blood
Serum
Alternative Complement Pathway
Immunoglobulin G
Eating
Classical Complement Pathway
Streptococcus agalactiae
Staphylococcus aureus
Escherichia coli

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Máródi, L., Leijh, P. C. J., Braat, A., Daha, M. R., & Van Furth, R. (1985). Opsonic activity of cord blood sera against various species of microorganism. Pediatric Research, 19(5), 433-436.

Opsonic activity of cord blood sera against various species of microorganism. / Máródi, L.; Leijh, Peter C J; Braat, Armando; Daha, Mohamed R.; Van Furth, Ralph.

In: Pediatric Research, Vol. 19, No. 5, 1985, p. 433-436.

Research output: Contribution to journalArticle

Máródi, L, Leijh, PCJ, Braat, A, Daha, MR & Van Furth, R 1985, 'Opsonic activity of cord blood sera against various species of microorganism', Pediatric Research, vol. 19, no. 5, pp. 433-436.
Máródi, L. ; Leijh, Peter C J ; Braat, Armando ; Daha, Mohamed R. ; Van Furth, Ralph. / Opsonic activity of cord blood sera against various species of microorganism. In: Pediatric Research. 1985 ; Vol. 19, No. 5. pp. 433-436.
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