Opposite regulation of uncoupling protein 1 and uncoupling protein 3 in vivo in brown adipose tissue of cold-exposed rats

P. B. Jakus, K. Sipos, G. Kispál, A. Sandor

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Earlier we reported a 14-fold increase of glycogen in the brown adipose tissue (BAT) in rats when the animals were placed back from cold to neutral temperature. To elucidate the mechanism, here we compared the level of glucose transporter 4 (GLUT4) protein, uncoupling protein (UCP) 1 and UCP3 mRNA and protein expressions in the BAT under the same conditions. We found that the increased GLUT4 level in cold was maintained during the reacclimation. After 1 week cold exposure the mRNA and protein content of UCP1 increased parallel, while the protein level of UCP3 decreased, contrary to its own mRNA level.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalFEBS Letters
Volume519
Issue number1-3
DOIs
Publication statusPublished - May 22 2002

Fingerprint

Brown Adipose Tissue
Rats
Facilitative Glucose Transport Proteins
Tissue
Messenger RNA
Proteins
Glycogen
Temperature
Animals
Uncoupling Protein 3
Uncoupling Protein 1

Keywords

  • Brown adipose tissue
  • Glucose transporter 4
  • Uncoupling protein

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Opposite regulation of uncoupling protein 1 and uncoupling protein 3 in vivo in brown adipose tissue of cold-exposed rats. / Jakus, P. B.; Sipos, K.; Kispál, G.; Sandor, A.

In: FEBS Letters, Vol. 519, No. 1-3, 22.05.2002, p. 210-214.

Research output: Contribution to journalArticle

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