Opposite effects of testosterone and estrogens on chronic allograft nephropathy

B. Antus, Yousheng Yao, Erwei Song, Shanying Liu, Jens Lutz, Uwe Heemann

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In the present study we investigated whether donor gender or the effects of sex hormones play the greater role in the development of chronic allograft nephropathy. Kidneys of male and female Fisher rats were orthotopically transplanted into castrated male Lewis recipients. Animals were treated with testosterone, estradiol, or vehicle and the kidneys were harvested 20 weeks after transplantation for histological, immunohistological, and molecular analysis. Testosterone treatment resulted in increased proteinuria and profound glomerulosclerosis, irrespective of donor gender. In addition, mRNA levels of transforming growth factor-β1 (TGF-β1) and platelet-derived growth factor-A and B (PDGF-A and B) chains were enhanced in these allografts. Estradiol reduced glomerulosclerosis and mononuclear cell infiltration in allografts of both genders that paralleled a decreased mRNA expression of TGF-β1, PDGF-A and B. No donor gender-related differences were noted in vehicle-treated animals. Our findings demonstrate that sex hormones rather than donor gender have a significant impact on chronic allograft nephropathy.

Original languageEnglish
Pages (from-to)494-501
Number of pages8
JournalTransplant International
Volume15
Issue number9-10
DOIs
Publication statusPublished - 2002

Fingerprint

Allografts
Testosterone
Estrogens
Gonadal Steroid Hormones
Transforming Growth Factors
Estradiol
Proto-Oncogene Proteins c-sis
Kidney
Messenger RNA
Proteinuria
Transplantation
platelet-derived growth factor A

Keywords

  • Chronic allograft nephropathy
  • Donor gender
  • Estrogens
  • Testosterone

ASJC Scopus subject areas

  • Transplantation

Cite this

Opposite effects of testosterone and estrogens on chronic allograft nephropathy. / Antus, B.; Yao, Yousheng; Song, Erwei; Liu, Shanying; Lutz, Jens; Heemann, Uwe.

In: Transplant International, Vol. 15, No. 9-10, 2002, p. 494-501.

Research output: Contribution to journalArticle

Antus, B. ; Yao, Yousheng ; Song, Erwei ; Liu, Shanying ; Lutz, Jens ; Heemann, Uwe. / Opposite effects of testosterone and estrogens on chronic allograft nephropathy. In: Transplant International. 2002 ; Vol. 15, No. 9-10. pp. 494-501.
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