Opposite effects of intraventricular and intracisternal administration of vasopressin on blood pressure in rats

Olaf Günther, Gábor L. Kovács, Gyula Szabó, Gyula Telegdy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Lysine-8-vasopressin (LVP) was injected into the lateral ventricle (ICV) or into the cisterna magna (c.m.) of ether-anesthetized rats. ICV injection of LVP decreased the blood pressure (BP), whereas c.m. administration increased it. The opposite effects of ICV versus c.m. administration of the peptide might be related to differences in brainstem versus limbic-midbrain structures in the regulation of blood pressure, and suggest that both mechanisms can be influenced by vasopressin.

Original languageEnglish
Pages (from-to)539-540
Number of pages2
JournalPeptides
Volume7
Issue number3
DOIs
Publication statusPublished - Jan 1 1986

Keywords

  • Blood pressure
  • Intracerebroventricular
  • Intracisternal
  • Lysine-8-vasopressin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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