Opposite effects of acute and chronic administration of alcohol on gastric emptying and small bowel transit in rat

F. Izbéki, T. Wittmann, Sándor Csáti, Erzsébet Jeszenszky, J. Lonovics

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The effects of acute and chronic administration of a large dose of alcohol on gastric emptying and small bowel transit were studied in rats. The development of tolerance to the acute effect of alcohol on gastrointestinal motility during chronic alcohol administration was also investigated. Gastric emptying and small intestinal transit were assessed by the Phenol Red recovery method. Acutely, ethanol was given in a dose of 2.5 g/kg body wt by gavage 30 min before the test meal. Chronically, ethanol was administered by two different methods: (1) a dose of 2.5 g/kg body wt was administered by gavage daily for 10 days; (2) animals received 15% ethanol in their drinking water for 30 days. A single large dose of alcohol inhibited gastric emptying and small bowel transit. Treatment with a large dose of alcohol for 10 days did not change the gastric emptying significantly, but inhibited the small intestinal transit. Alcohol consumption in drinking water for 30 days accelerated gastric emptying and small bowel transit. Tolerance to the acute inhibitory effect of a single large dose of alcohol on gastrointestinal motility did not develop during chronic alcohol treatment.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalAlcohol and Alcoholism
Volume36
Issue number4
Publication statusPublished - 2001

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Gastric Emptying
Rats
Alcohols
Gastrointestinal Motility
Ethanol
Drinking Water
Phenolsulfonphthalein
Alcohol Drinking
Meals
Animals
Recovery

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Opposite effects of acute and chronic administration of alcohol on gastric emptying and small bowel transit in rat. / Izbéki, F.; Wittmann, T.; Csáti, Sándor; Jeszenszky, Erzsébet; Lonovics, J.

In: Alcohol and Alcoholism, Vol. 36, No. 4, 2001, p. 304-308.

Research output: Contribution to journalArticle

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